Miralys™ Photocleavable Mass-tag Tissue Imaging Probes
Mass spectrometric color image of human tonsil tissue produced using highly multiplex MALDI-IHC.
The mass spectrum shown is a superposition of spectra from seven selected pixels in the image.
A New Technology for Spatial Biology Imaging
▶ Multiplex. Capable of 100+ biomarkers. Single scan, no cycling. Every probe has a unique tag.
▶ Multimodal. One sample → results from many imaging modalities.
▶ Multiomic. One workflow→ Small molecules, intact proteins and other macromolecules, and glycosylation.
▶ Easy Workflow. No conjugation. One staining step. No metal tags.
▶ Familiar Methods. Leverages traditional MSI and IHC methods and equipment.
▶ Fast. Image entire slide in 40 min. Drill down to ROIs at higher res.
▶ Reliable Platform. Developed using mass spectrometers from Bruker.
Improving the Accuracy of Diagnostic Tests
The “Matrix Effect” limits the sensitivity, specificity and quantitative accuracy of diagnostic immunoassays. This results from interference caused by a litany of non-target agents in complex biosamples such as blood. This effect is especially problematic for the new generation of multiplex assays where a panel of biomarkers are simultaneously detected. PC-PURE™ utilizes photocleavable binding agents such as antibodies to capture only the target molecules in a patient sample, effectively eliminating the Matrix Effect.
- AmberGen announces that Dr. Michael Easterling, PhD will join Board of Directors April 2022
- AmberGen Announces New Appointments for John Gillespie & Dr. Kenneth J. Rothschild April 2022
- AmberGen and Bruker Collaborate on Spatial Biology Imaging Reagents for MALDI-Immunohistochemistry (MALDI-IHC) April 2022
- Dr. Mark Lim of AmberGen was honored to be an invited keynote speaker at the “Innovation in Mass Spectrometry Imaging Omics” Session March 2022